Gentamicin dosing
Do NOT use if previous vestibular or auditory toxicity or serious hypersensitivity (rare) due to aminoglycosidesSevere sepsis or septic shock: A single gentamicin dose of 7 mg/kg. Subsequent dosing is adjusted in accordance with renal function (calculated creatinine clearance).
Severe sepsis: 7 mg/kg up to 640 mg (sepsis syndrome)
No evidence of severe sepsis: initial dose based on age, and subsequent dosing determined by renal function (calculated creatinine clearance) (see below)
Obese patients: Ideal body weight for aminoglycoside dose calculation, however do not delay FIRST DOSE if this is not available. Cap dose at 640mg
Empiric therapy: Use for a maximum of 48 hours as pending outcome of investigation.
NO levels required for empiric dosing (up to 3 doses)
| Number of doses(calculated creatinine clearance) | ||
|---|---|---|
| GFR > 60 mL/min | 5mg/kg IV | 24 hourly for 3 doses |
| GFR 40-60 mL/min | 4-5mg/kg | 36 hourly for 2 doses |
| GFR < 40ml/min | 4mg/kg | single dose |
Directed therapy: (beyond 48 hours, based on microbiology results) should be used on the advice of Infectious Diseases only and requires registration on Guidance® Stewardship program